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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > RolipramCAS：61413-54-5
Molecular Formula：C16H21NO3
Molecular Weight：275.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：White to off-white Solid
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| CAS | 61413-54-5 |
| Name | Rolipram |
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥97% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 262-771-1 |
| MDL | MFCD00270906 |
| SMILES | O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1 |
| InChIKey | HJORMJIFDVBMOB-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) |
| PubChem CID | 5092 |
| Target Point | PDE inhibitor |
| Passage | Metabolic Enzyme&Protease |
| Background | Rolipram is a selective phosphodiesterase PDE4 inhibitor. |
| Biological Activity | Rolipram 是一种选择性的磷酸二酯酶 PDE4 抑制剂，抑制 PDE4A，PDE4B 和 PDE4D，的 IC50 分别为 3 nM，130 nM 和 240 nM。[1] |
| IC50 | 3nM(PDE4A)，130nM(PDE4B)，240nM(PDE4D)[1] |
| Data Literature Source | [1]. MacKenzie SJ，et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr [2]. Korhonen R，et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36. [3]. Shalaby AM，et al. Effect of rolipram，a phosphodiesterase enzyme type-4 inhibitor，on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7. |
| Unit | Piece |
| Specification | 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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