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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > E-64CAS：66701-25-5
Molecular Formula：C15H27N5O5
Molecular Weight：357.41
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 66701-25-5 |
| Name | E-64 |
| Molecular Formula | C15H27N5O5 |
| Molecular Weight | 357.41 |
| Solubility | Soluble in Water/DMSO≥10mg/mL；Soluble in Ethanol＜1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 613-978-4 |
| MDL | MFCD00080261 |
| SMILES | O=C([C@H]1O[C@@H]1C(N[C@H](C(NCCCCNC(N)=N)=O)CC(C)C)=O)O |
| Target Point | Cysteine Protease inhibitor |
| Passage | Metabolic Enzyme&Protease |
| Background | E-64 is a potent and irreversible inhibitor of cysteine proteases. Also inhibits papain, calpain and cathepsins B, H, but not serine or aspartic proteases. Oxidative stress and apoptosis can be induced in filarial parasites. |
| Biological Activity | E-64 是一种有效的不可逆的半胱氨酸蛋白酶 (cysteine proteases) 抑制剂，抑制 papain 的 IC50 为 9 nM[1]。 |
| IC50 | 9nM(Papain)[1] |
| Data Literature Source | [1]. Matsumoto K，et al. Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. Biopolymers. 1999;51(1):99-107. [2]. Wadhawan M，et al. Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite. PLoS One. 2014 Mar 25;9(3):e93161. [3]. Baldzizhar R，et al. Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem. 2013 Jan 18;288(3):1612-9. [4]. Blass G，et al. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiol Rep. 2016 Sep;4(17). pii: e12950 |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mM*1mL in Water 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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CoCl 2 increases the expression of hypoxic markers HIF-1α, VEGF and CXCR4 in breast cancer MCF-7 cells
Click to check >>Author：Li Q , Ma R , Zhang M .
IF：2.7850
Publish_to：Oncol Lett.
PMID：29391899
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