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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Sunitinib MalateCAS：341031-54-7
Molecular Formula：C22H27FN4O2·C4H6O5
Molecular Weight：532.56
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Light yellow to brown Solid
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| CAS | 341031-54-7 |
| Name | Sunitinib Malate |
| Molecular Formula | C22H27FN4O2·C4H6O5 |
| Molecular Weight | 532.56 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 638-825-9 |
| MDL | MFCD08282795 |
| SMILES | O=C(NCCN(CC)CC)C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)F)=O)=C1C)C.O=C([C@H](CC(O)=O)O)O |
| Target Point | PDGFR;VEGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Sunitinib Malate is a potent tyrosine kinase inhibitor that inhibits VEGFR2 and PDGFRβ. |
| Biological Activity | Sunitinib Malate (formerly also known as SU11248 Malate; trade nameSutent)) is a potent, orally bioavailable and multi-targeted RTK (receptor tyrosine kinase) inhibitor with potent anticancer activities. It inhibits VEGFR2 (Flk-1) and PDGFRβ with IC50s of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. It was approved by the FDA for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor on January 26, 2006. Sunitinib Malate is the malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of VEGFR2, PDGFRb, and c-kit, thereby inhibiting angiogenesis and cell proliferation. [1] |
| Data Literature Source | [1]. J Med Chem. 2003;46(7):1116-9; Clin Cancer Res. 2003;9(1):327-37; Blood. 2003;101(9):3597-605. [2]. Sun L，et al. J Med Chem，2003，46(7)，1116-1119. |
| Unit | Piece |
| Specification | 50mg 10mM*1mL in DMSO 100mg 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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