| CAS |
6893/2/3 |
| Chinese Name |
三碘甲状腺氨酸 |
| English Name |
Triiodothyronine |
| Synonyms |
T3;O-(4-Hydroxy-3-iodophenyl)-3，5-diiodo-L-tyrosine;L-3，3，5-Tresitope;3，3，5-Triiodo-L-thyronine;Lyothyronine;碘噻罗宁 |
| Molecular Formula |
C15H12I3NO4 |
| Molecular Weight |
650.97 |
| Solubility |
Soluble in DMSO ≥10mg/mL，Soluble in Ethanol < 1mg/mL；Soluble in Water< 3mg/mL |
| Purity |
≥98% |
| Appearance |
White to brown Solid |
| Storage |
Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 229-999-3 |
| MDL |
MFCD00002593 |
| SMILES |
OC1=C(I)C=C(OC2=C(I)C=C(C[C@H](N)C(O)=O)C=C2I)C=C1 |
| InChIKey |
AUYYCJSJGJYCDS-LBPRGKRZSA-N |
| InChI |
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 |
| PubChem CID |
5920 |
| Target Point |
Thyroid Hormone Receptor |
| Passage |
Endocrinology & Hormones |
| Background |
It is a potent agonist of thyroid hormone receptors TRα and TRβ. |
| Biological Activity |
3,3',5-Triiodo-L-thyronine是有效的甲状腺激素受体 TRα 和 TRβ 的激动剂，Ki 值为2.3 nM。[1-2] |
| In Vitro |
3，3'，5-三碘-L-甲状腺素(T3，100nM)刺激TRβ1过表达的肝细胞增殖[1]。 3，3'，5-三碘-L-甲状腺素与人β1甲状腺激素受体(hTRβ1)结合，并改变其构象。 3，3'，5-三碘-L-甲状腺素促进生长，诱导分化并调节代谢作用[2]。 |
| Cell Experiment |
制备甲状腺激素耗尽(Td)血清。进行甲基纤维素中肝癌细胞的生长。为了确定3，3'，5-三碘-L-甲状腺素(T3)对细胞生长的影响，在第0天将细胞以3×10 4个细胞/ 60mm培养皿的密度接种，并在含有培养基的培养基中培养。 5％常规血清，5％Td或5％Td和100nM T3。初始接种后3周，甲基纤维素中的集落形成评分[1]。 |
| Data Literature Source |
[1]. Lin KH， et al. Stimulation of proliferation by 3，3'，5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14; 85 (2) :189-94.
[2]. Bhat MK， et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3，3'，5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31; 195 (1) :385-92. |
| Unit |
Piece |
| Specification |
50mg 10mM*1mL in DMSO 100mg 500mg |
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