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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > TEPP-46CAS：1221186-53-3
Molecular Formula：C17H16N4O2S2
Molecular Weight：372.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Appearance：White to yellow Solid
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| CAS | 1221186-53-3 |
| Name | TEPP-46 |
| Molecular Formula | C17H16N4O2S2 |
| Molecular Weight | 372.46 |
| Solubility | Soluble in DMSO |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD23160747 |
| SMILES | O=C1C(N(C)C2=C3SC(S(C)=O)=C2)=C3C=NN1CC4=CC=CC(N)=C4 |
| Target Point | Pyruvate Kinase |
| Passage | Metabolic Enzyme&Protease |
| Background | TEPP-46/mL-265 is a novel potent and selective small molecule activator of pyruvate kinase M2 (PKM2) |
| Biological Activity | TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM， showing little or no effect on PKM1， PKL and PKR.[1-2] |
| Data Literature Source | [1]. Anastasiou D， et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct;8(10):839-847. [2]. Palsson-McDermott EM， et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015 Jan 6;21(1):65-80. |
| Unit | Piece |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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