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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > U-73122CAS：112648-68-7
Molecular Formula：C29H40N2O3
Molecular Weight：464.64
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 112648-68-7 |
| Name | U-73122 |
| Molecular Formula | C29H40N2O3 |
| Molecular Weight | 464.64 |
| Solubility | Soluble in DMSO ≥0.5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD00008350 |
| SMILES | O=C(C=C1)N(CCCCCCN[C@H]2CC[C@@]3([H])[C@]4([H])CCC5=C(C=CC(OC)=C5)[C@@]4([H])CC[C@]23C)C1=O |
| Target Point | Phospholipase |
| Passage | Metabolic Enzyme&Protease |
| Background | U-73122 is a potent phospholipase C (phospholipase C), phospholipase A2 (phospholipase A2) and 5-lipoxygenase (5-LO (5-lipoxygenase)) inhibitor. |
| Biological Activity | U-73122 是有效的 磷脂酶C (phospholipase C)，磷脂酶A2 (phospholipase A2) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂。[1-5] |
| Data Literature Source | [1]. Smith RJ，et al. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther. 1990 May;253(2):688-97. [2]. Bleasdale JE，et al. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther. 1990 Nov;255(2):756-68. [3]. Thompson AK，et al. The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation. J Biol Chem. 1991 Dec 15;266(35):23856-62. [4]. Peng T，et al. Disruption of phospholipase Cgamma1 signalling attenuates cardiac tumor necrosis factor-alpha expression and improves myocardial function during endotoxemia. Cardiovasc Res. 2008 Apr 1;78(1):90-7. Epub 2007 Dec 12. [5]. Frye CA，et al. In the ventral tegmental area，the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C. J Neuroendocrinol. 2007 Sep;19(9):717-24 |
| Unit | Piece |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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