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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Y-27632 dihydrochlorideCAS：129830-38-2
Molecular Formula：C14H21N3O·2HCl
Molecular Weight：320.26
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 129830-38-2 |
| Name | Y-27632 dihydrochloride |
| Molecular Formula | C14H21N3O·2HCl |
| Molecular Weight | 320.26 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 813-428-5 |
| MDL | MFCD03490488 |
| SMILES | O=C([C@@H]1CC[C@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2.[H]Cl.[H]Cl |
| Target Point | ROCK |
| Passage | Cytoskeleton; Cell Cycle;TGF-beta/Smad;Stem Cells |
| Background | Y-27632 dihydrochloride is an ATP-competitive ROCK-I and ROCK-II inhibitor. |
| Biological Activity | Y-27632 dihydrochloride 是 ATP 竞争性的 ROCK-I 和 ROCK-II 抑制剂，Ki 分别为 220 nM 和 300 nM。[1-4] |
| Data Literature Source | [1]. Ishizaki T，et al. Pharmacological properties of Y-27632，a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83. [2]. Xue ZW，et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J (Engl). 2012 Sep;125(18):3332-5. [3]. Inan S，et al. Antiepileptic effects of two Rho-kinase inhibitors，Y-27632 and fasudil，in mice. Br J Pharmacol. 2008 Sep;155(1):44-51. [4]. Tada S，et al. A selective ROCK inhibitor，Y27632，prevents dimethylnitrosamine-induced hepatic fibrosis in rats. J Hepatol. 2001 Apr;34(4):529-36. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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