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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > ZebularineCAS：3690/10/6
Molecular Formula：C9H12N2O5
Molecular Weight：228.2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 3690/10/6 |
| Name | Zebularine |
| Molecular Formula | C9H12N2O5 |
| Molecular Weight | 228.2 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 2017-001-1 |
| MDL | MFCD04973699 |
| SMILES | O=C1N=CC=CN1[C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O |
| Target Point | DNA Methyltransferase |
| Passage | Epigenetics |
| Background | Zebularine is a DNA methyltransferase inhibitor; also a cytidine deaminase inhibitor. |
| Biological Activity | Zebularine 是DNA甲基转移酶抑制剂；也是胞苷脱氨酶抑制剂，Ki值为0.95 μM。Zebularine通过稳定DNMT与DNA的结合，阻碍甲基化和减少解离来发挥其去甲基化活性，从而捕获酶并防止甚至在其他部位的转换。 [1-4] |
| Data Literature Source | [1]. Champion C，et al. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One. 2010 Aug 24;5(8):e12388. [2]. Cheng JC，et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst. 2003 Mar 5;95(5):399-409. [3]. Billam M，et al. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res Treat. 2010 Apr;120(3):581-92. [4]. Lemaire M，et al. Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine. Cancer Chemother Pharmacol. 2009 Feb;63(3):411-6 |
| Unit | Bottle |
| Specification | 10mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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