Bosutinib
Cat.No:IB0740 Solarbio
CAS:380843-75-4
Molecular Formula:C26H29Cl2N5O3
Molecular Weight:530.45
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥99%
Appearance:White to yellow Solid
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Small Molecule Compounds >
Inhibitors & Antagonists & Agonists >
Protein Tyrosine Kinase/PTK >
BosutinibCAS:380843-75-4
Molecular Formula:C26H29Cl2N5O3
Molecular Weight:530.45
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥99%
Appearance:White to yellow Solid
Qty:
Size:
CAS | 380843-75-4 |
Name | Bosutinib |
Molecular Formula | C26H29Cl2N5O3 |
Molecular Weight | 530.45 |
Solubility | Soluble in DMSO |
Purity | ≥99% |
Appearance | White to yellow Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 700-455-1 |
MDL | MFCD07367846 |
SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC |
Target Point | Src;Abl |
Passage | Protein Tyrosine Kinase/RTK |
Background | Bosutinib is a dual inhibitor of Src/Abl. |
Biological Activity | Bosutinib(SKI-606) is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.[1] |
IC50 | Src: 1.2nM;Abl: 1nM[1] |
Data Literature Source | [1]. Boschelli DH,et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem,2001,44(23),3965-3977. [2]. Vultur A,et al. SKI-606 (bosutinib),a novel Src kinase inhibitor,suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther,2008,7(5),1185-1194. [3]. Golas JM,et al. SKI-606,a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res,2005,65(12),5358-5364. |
Unit | Bottle |
Specification | 10mg 20mg 100mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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