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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > CanertinibCAS：267243-28-7
Molecular Formula：C24H25ClFN5O3
Molecular Weight：485.94
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 267243-28-7 |
| Name | Canertinib |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years |
| EC | EINECS 1308068-626-2 |
| MDL | MFCD09837878 |
| SMILES | O=C(NC1=C(C=C2C(C(NC3=CC=C(C(Cl)=C3)F)=NC=N2)=C1)OCCCN4CCOCC4)C=C |
| Target Point | EGFR;ErbB2 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | Canertinib is a potent, irreversible EGFR inhibitor. |
| Biological Activity | Canertinib 是有效地，不可逆的 EGFR 抑制剂；抑制细胞 EGFR 和 ErbB2 自身磷酸化的 IC50 值分别为7.4和9 nM[1-2]。 |
| IC50 | EGFR:7.4nM ErbB2:9nM [1-2] |
| Data Literature Source | [1]. Smaill JB，et al. Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3，2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J Med Chem. 2000 Apr 6;43(7):1380-97. [2]. Djerf Severinsson EA，et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414(3):563-8 |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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