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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Erlotinib HydrochlorideCAS：183319-69-9
Molecular Formula：C22H23N3O4·HCl
Molecular Weight：429.9
Storage：Powder:2-8℃，2 years
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 183319-69-9 |
| Name | Erlotinib Hydrochloride |
| Molecular Formula | C22H23N3O4·HCl |
| Molecular Weight | 429.9 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| EC | EINECS 620-491-0 |
| MDL | MFCD07781272 |
| SMILES | COCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC.[H]Cl |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | Erlotinib inhibits EGFR kinase. |
| Biological Activity | Erlotinib 抑制 EGFR 激酶的 IC50 为 2 nM。[1-4] |
| IC50 | EGFR:2nM [1-4] |
| Data Literature Source | [1]. Moyer JD，et al. Induction of apoptosis and cell cycle arrest by CP-358，774，an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48. [2]. Ali S，et al. Apoptosis-inducing effect of erlotinib is potentiated by 3，3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther，2008，7(6)，1708-1719. [3]. Marchetti S，et al. Effect of the ATP-binding cassette drug transporters ABCB1，ABCG2，and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-typ [4]. Adachi K，et al. Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. J Toxicol Sci. 2010 Aug;35(4):503-14 |
| Unit | Bottle |
| Specification | 100mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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