{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Lapatinib DitosylateCAS：388082-77-7
Molecular Formula：C29H26ClFN4O4S·2C7H8O3S
Molecular Weight：925.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 388082-77-7 |
| Name | Lapatinib Ditosylate |
| Molecular Formula | C29H26ClFN4O4S·2C7H8O3S |
| Molecular Weight | 925.46 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1312995-182-4 |
| MDL | MFCD09264195 |
| SMILES | O=S(CCNCC1=CC=C(C2=CC=C3C(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N3)=C2)O1)(C)=O.O=S(C6=CC=C(C)C=C6)(O)=O.O=S(C7=CC=C(C)C=C7)(O)=O |
| Target Point | EGFR;ErbB2，ErbB4 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | Lapatinib Ditosylate is an EGFR and ErbB2 inhibitor. |
| Biological Activity | Lapatinib ditosylate(GW-572016 ditosylate)是EGFR和ErbB2抑制剂，IC50分别为10.8和9.2 nM。[1-3] |
| Data Literature Source | [1]. Rusnak DW，et al. The effects of the novel，reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor，GW2016，on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94. [2]. O'Neill F，et al. Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines. Mol Cancer. 2012 Jun 18;11(1):41. [3]. Eryilmaz U，et al. S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. PLoS One. 2015 Dec 18;10(12):e0145418. |
| Unit | Bottle |
| Specification | 25mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
