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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > HIF > RoxadustatCAS：808118-40-3
Molecular Formula：C19H16N2O5
Molecular Weight：352.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 808118-40-3 |
| Name | Roxadustat |
| Molecular Formula | C19H16N2O5 |
| Molecular Weight | 352.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 813-400-2 |
| MDL | MFCD20040519 |
| SMILES | O=C(O)CNC(C1=C(O)C2=C(C(C)=N1)C=C(OC3=CC=CC=C3)C=C2)=O |
| Target Point | HIF/HIF Prolyl-Hydroxylase |
| Passage | HIF |
| Background | Roxadustat is a prolyl hydroxylase HIF inhibitor. |
| Biological Activity | Roxadustat (FG-4592) 是一种脯氨酰羟化酶 HIF 抑制剂，开发用于治疗贫血症。[1-2] |
| Data Literature Source | [1]. Liu H，et al. Prolyl-4-Hydroxylases Inhibitor Stabilizes HIF-1α and Increases Mitophagy to Reduce Cell Death After Experimental Retinal Detachment. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):1807-15. [2]. Yu Y，et al. Hypoxia enhances tenocyte differentiation of adipose-derived mesenchymal stem cells by inducing hypoxia-inducible factor-1α in a co-culture system. Cell Prolif. 2016 Apr;49(2):173-84. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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