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NVP-AEW541

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Cat.No：IN0770 Solarbio

CAS：475489-16-8

Molecular Formula：C₂₇H₂₉N₅O

Molecular Weight：439.55

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	475489-16-8
Name	NVP-AEW541
Molecular Formula	C₂₇H₂₉N₅O
Molecular Weight	439.55
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
Target Point	IGF-1R
Passage	Protein Tyrosine Kinase/RTK
Background	NVP-AEW541 is a potent IGF-1R inhibitor.
Biological Activity	NVP-AEW541 是一种有效的 IGF-1R 抑制剂，IC50 为 0.15 μM，也抑制 InsR，IC50 为 0.14 μM[1-2]。
IC50	0.15 ±0.036μM(IGF-IR);0.14±0.039μM(InsR);0.42±0.11μM(Flt-3);2±0.61μM(PDGFR);2.4±0.38μM(c-Src);3.3±1.4μM(c-Kit)[1]
Data Literature Source	[1]. García-Echeverría C，et al. In vivo antitumor activity of NVP-AEW541-A novel，potent，and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9. [2]. Tanno B，et al. Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res. 2006，12(22)，6772-6780.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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