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Pazopanib Hydrochloride

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Cat.No：IP1300 Solarbio

CAS：635702-64-6

Molecular Formula：C₂₁H₂₃N₇O₂S·HCl

Molecular Weight：473.98

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	635702-64-6
Name	Pazopanib Hydrochloride
Molecular Formula	C₂₁H₂₃N₇O₂S·HCl
Molecular Weight	473.98
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 619-728-0
MDL	MFCD12546138
SMILES	CC1=CC=C(C=C1S(N)(=O)=O)NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C)C)=N2.Cl
Target Point	PDGFR;VEGFR1;VEGFR2;VEGFR3;PDGFR;FGFR;c-Kit;c-fms
Passage	Angiogenesis; Protein Tyrosine Kinase/RTK
Background	Pazopanib is a multi-target inhibitor.
Biological Activity	Pazopanib (GW786034) 是多靶点抑制剂，抑制 VEGFR1，VEGFR2，VEGFR3，PDGFRβ，c-Kit，FGFR1，c-Fms的IC50分别为10，30，47，84，74，140，146 nM。[1-2]
Data Literature Source	[1]. Harris PA，et al. Discovery of 5-[[4-[(2，3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib)，a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008，51(15)，4632-4640. [2]. Thakur A，et al. Pazopanib，a multitargeted tyrosine kinase inhibitor，reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82(3):346-50.
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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