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Perifosine

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Cat.No：IP1320 Solarbio

CAS：157716-52-4

Molecular Formula：C₂₅H₅₂NO₄P

Molecular Weight：461.66

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	157716-52-4
Name	Perifosine
Molecular Formula	C₂₅H₅₂NO₄P
Molecular Weight	461.66
Solubility	Soluble in Water ≥1mg/mL
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 690-653-3
MDL	MFCD00927554
SMILES	[O-]P(OC1CC[N+](C)(CC1)C)(OCCCCCCCCCCCCCCCCCC)=O
Target Point	Akt
Passage	PI3K/Akt/mTOR
Background	Perifosine is a potent Akt inhibitor.
Biological Activity	Perifosine 是一种口服有效的 Akt 抑制剂。Perifosine 对绝大多数细胞具有抗增殖活性，IC50 为 0.6-8.9 μM。[1-3]
Data Literature Source	[1]. Momota H，et al. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res，2005，65(16)，7429-7435. [2]. Vyomesh Patel，et al. Perifosine，a novel alkylphospholipid，induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway，leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res，2002，62(5)，14 [3]. Chen L，et al. Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures. Epilepsia. 2012 Nov;53(11):2026-33
Unit	Bottle
Specification	5mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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