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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > PI 103CAS：371935-74-9
Molecular Formula：C19H16N4O3
Molecular Weight：348.36
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 371935-74-9 |
| Name | PI 103 |
| Molecular Formula | C19H16N4O3 |
| Molecular Weight | 348.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11983145 |
| SMILES | OC1=CC(C2=NC3=C(C(N4CCOCC4)=N2)OC5=C3C=CC=N5)=CC=C1 |
| Target Point | PI3K;mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | PI-103 is a potent PI3K and mTOR inhibitor. |
| Biological Activity | PI-103 是一种有效的 PI3K 和 mTOR 抑制剂，抑制 p110α，p110β，p110δ，p110γ，mTORC1 和 mTORC2，IC50 分别为 8 nM，88 nM，48 nM，150 nM，20 nM 和 83 nM。PI-103 还抑制 DNA-PK，IC50 为 2 nM。[1-4] |
| IC50 | p110α:8nM;PI3KC2β:26nM;DNA-PK:2nM [1-4] |
| Data Literature Source | [1]. Raynaud FI，et al. Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103through PI-540，PI-620 to the oral agent GDC-0941. Mol Cancer Ther. 2009 Jul;8(7):1725-39. [2]. Park S，et al. PI-103，a dual inhibitor of Class IA phosphatidylinositide 3-kinase anLeukemia. 2008 Sep;22(9):1698-706.d mTOR，has antileukemicactivity in AmL. Leukemia. 2008 Sep;22(9):1698-706. [3]. López-Fauqued M，et al. The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression，in vivo tumor growth and increases survival of sorafenib-treated melanoma cells. Int J Cancer. 2010 Apr 1;126(7):1549-61. [4]. Knight ZA，et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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