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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Trichostatin ACAS：58880-19-6
Molecular Formula：C17H22N2O3
Molecular Weight：302.37
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 58880-19-6 |
| Name | Trichostatin A |
| Molecular Formula | C17H22N2O3 |
| Molecular Weight | 302.37 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 611-758-2 |
| MDL | MFCD03848392 |
| SMILES | CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(NO)=O)C)C)=O)C |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Trichostatin A is a potent, specific histone deacetylase class I and II (HDAC class I/II) inhibitor. |
| Biological Activity | Trichostatin A 是有效的，特异的组蛋白去乙酰化酶类型 I 和 II (HDAC class I/II) 抑制剂，对 HDAC 的 IC50 值为 1.8 nM。[1-4] |
| IC50 | HDAC:1.8nM |
| Data Literature Source | [1]. Vigushin DM et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 2001 Apr;7(4):971-6. [2]. Karolczak-Bayatti M，et al. Expression of the GTP-Binding Protein Gαs in Human Myometrial Cells is Regulated by Ubiquitination and Protein Degradation: Involvement of Proteasomal Inhibition by Trichostatin A.，Reprod Sci. 2012 Aug 8. [3]. Hu X，et al. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner.，Stem Cells Dev. 2012 Aug 8. [4]. Azechi T，et al. Trichostatin A，an HDAC class I/II inhibitor，promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. J Atheroscler Thromb. 2013;20(6):538-47 |
| Unit | Bottle |
| Specification | 1mg 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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