{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > BrivanibCAS：649735-46-6
Molecular Formula：C19H19FN4O3
Molecular Weight：370.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 649735-46-6 |
| Name | Brivanib |
| Molecular Formula | C19H19FN4O3 |
| Molecular Weight | 370.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD13194684 |
| SMILES | FC1=C(OC2=NC=NN3C2=C(C(OC[C@H](O)C)=C3)C)C=CC4=C1C=C(C)N4 |
| Target Point | VEGFR2/KDR/Flk-1;FGFR2 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Brivanib is an ATP-competitive VEGFR2 inhibitor. |
| Biological Activity | Brivanib 是一种ATP竞争性的 VEGFR2 抑制剂，IC50 值为 25 nM；可以适度抑制 VEGFR-1 和 FGFR-1，对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍[1-3]。 |
| IC50 | VEGFR2:25nM [1-3] |
| Data Literature Source | [1]. Bhide RS，et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2，1-f][1，2，4]triazin-6-yloxy)propan- 2-ol (BMS-540215)，an in vivo active potent VEGFR-2 inhibitor. J Med Chem，2006，49 (7)，2143-2146. [2]. Huynh H，et al. Brivanib alaninate，a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases，induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res，2008， [3]. Nakamura I，et al. Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF，VEGF and PDGF Signaling. PLoS One. 2015 Nov 3;10(11):e0142355 |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
