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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > EntinostatCAS：209783-80-2
Molecular Formula：C21H20N4O3
Molecular Weight：376.41
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 209783-80-2 |
| Name | Entinostat |
| Molecular Formula | C21H20N4O3 |
| Molecular Weight | 376.41 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08272435 |
| SMILES | O=C(NCC1=CC=C(C=C1)C(NC2=CC=CC=C2N)=O)OCC3=CC=CN=C3 |
| InChIKey | INVTYAOGFAGBOE-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26) |
| PubChem CID | 4261 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Entinostat is a selective HDAC class I inhibitor. |
| Biological Activity | Entinostat 选择性，可口服的 HDAC class I 抑制剂，抑制 HDAC1，HDAC2 和 HDAC3 的 IC50 分别为 243 nM，453 nM 和 248 nM。[1-4] |
| IC50 | HDAC1:243nM;HDAC3:248nM;HDAC2:453nM [1-4] |
| Data Literature Source | [1]. Lauffer BE，et al. Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem. 2013 Sep 13;288(37):26926-43. [2]. Rosato RR，et al. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Res. 2003 Jul 1;63(13):36 [3]. Saito A，et al. A synthetic inhibitor of histone deacetylase，MS-27-275，with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci U S A，1999，96(8)，4592-4597. [4]. Zhang ZY，et al. MS-275，an histone deacetylase inhibitor，reduces the inflammatory reaction in rat experimental autoimmune neuritis. Neurosci，2010，169，370-377. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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