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Ailanthone

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Cat.No：IA1430 Solarbio

CAS：981-15-7

Molecular Formula：C₂₀H₂₄O₇

Molecular Weight：376.4

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	981-15-7
Name	Ailanthone
Molecular Formula	C₂₀H₂₄O₇
Molecular Weight	376.4
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 683-145-8
MDL	MFCD01729487
SMILES	C[C@@]1([C@@H]2O)[C@]([C@@]3([C@@H]4O)O)([H])[C@@]([C@](C5)([H])C4=C)(CO3)[C@@](OC5=O)([H])C[C@@]1([H])C(C)=CC2=O
Target Point	Androgen Receptor
Passage	Endocrinology & Hormones
Background	Ailanthone is a potent androgen receptor (AR) inhibitor that inhibits the intact androgen receptor.
Biological Activity	Ailanthone是有效的Androgen receptor (AR)) 抑制剂，抑制完整雄激素受体，和持续活跃剪切变体的 IC50 值分别为 69 nM 和309 nM[1]。
IC50	69 nM(Full-length androgen receptor)，309 nM(AR1-651)[1]
Data Literature Source	[1]. He Y，et al. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat Commun. 2016 Dec 13;7:13122. [2]. Zhuo Z，et al. Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo. Sci Rep. 2015 Nov 3;5:16185
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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