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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > ColumbinCAS：546-97-4
Molecular Formula：C20H22O6
Molecular Weight：358.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 546-97-4 |
| Name | Columbin |
| Molecular Formula | C20H22O6 |
| Molecular Weight | 358.39 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD02682955 |
| SMILES | O=C1[C@](C=C2)(O)[C@@](CC3)(C)[C@@]([C@@](C[C@@H](C4=COC=C4)O5)(C)[C@]3([H])C5=O)([H])[C@]2([H])O1 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Columbin is a diterpenoid spironolactone with anti-inflammatory activity. |
| Biological Activity | Columbin是具有抗炎活性的二萜类螺内酯。[1-2] |
| Data Literature Source | [1]. Ibrahim Abdelwahab S， et al. In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation. Eur J Pharmacol. 2012 Mar 5; 678 (1-3) :61-70. [2]. Yang G， et al. Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption， metabolism， and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1; 1002:13-8 |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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