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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Vincristine sulfateCAS：2068-78-2
Molecular Formula：C46H58N4O14S
Molecular Weight：923.04
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 2068-78-2 |
| Name | Vincristine sulfate |
| Molecular Formula | C46H58N4O14S |
| Molecular Weight | 923.04 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 218-190-0 |
| MDL | MFCD00084729 |
| SMILES | CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C4=CC([C@](C5=C6C7=CC=CC=C7N5)(C[C@](C[C@](CC)(O)C8)([H])C[N@@]8CC6)C(OC)=O)=C(OC)C=C4N9C=O)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O.O=S(O)(O)=O |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | Vincristine sulfate is an alkaloid that inhibits microtubule formation in the mitotic spindle, resulting in arrest of dividing cells in metaphase. Inhibits microtubule polymerization by binding to tubulin |
| Biological Activity | Vincristine sulfate是一种抗肿瘤长春花生物碱，抑制有丝分裂纺锤体中的 microtubule 形成，导致中期阶段的分裂细胞停滞。 它与 microtubule 结合的 Ki 为85 nM。[1-6] |
| Data Literature Source | [1]. Jordan， M.A.， et al. Comparison of the effects of vinblastine， vincristine， vindesine， and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res， 1985. 45 (6) : p. 2741-7. [2]. Gidding， C.E.， et al， Vincristine revisited. Crit Rev Oncol Hematol， 1999. 29 (3) : p. 267-87. [3]. Donoso， J.A.， et al， Action of the vinca alkaloids vincristine， vinblastine， and desacetyl vinblastine amide on axonal fibrillar organelles in vitro. Cancer Res， 1977. 37 (5) : p. 1401-7. [4]. Horton， J.K.， et al. Relationships between tumor responsiveness， vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts. Biochem Pharmacol， 1988. 37 (20) : p. 3995-4000. [5]. Baguley， B.C.， et al， Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer， 1991. 27 (4) : p. 482-7. [6]. Zhang D， et al. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. Int J Nanomedicine. 2017 Mar 16; 12:2081-2108. |
| Unit | Bottle |
| Specification | 5mg 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Click to check >>Author：YuanXW;YanTQ;TongH
IF：3.6360
Publish_to：Cancer Manag Res
PMID：33262657
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