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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > 3-AminobenzamideCAS：3544-24-9
Molecular Formula：C7H8N2O
Molecular Weight：136.15
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 3544-24-9 |
| Name | 3-Aminobenzamide |
| Molecular Formula | C7H8N2O |
| Molecular Weight | 136.15 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 222-586-9 |
| MDL | MFCD00007989 |
| SMILES | O=C(C1=CC=CC(N)=C1)N |
| InChIKey | GSCPDZHWVNUUFI-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10) |
| PubChem CID | 1645 |
| Target Point | PARP |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | 3-Aminobenzamide is a potent PARP inhibitor. |
| Biological Activity | 3-Aminobenzamide 是一种有效的 PARP 抑制剂, 在 CHO 细胞中, 对 PARP 的 IC50 值约为 50 nM[1-4]。 |
| IC50 | PARP:50nM (IC50) [1-4] |
| Data Literature Source | [1]. Brock WA， et al. Radiosensitization of human and rodent cell lines by INO-1001， a novel inhibitor of poly (ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18; 205 (2) :155-60. [2]. Radovits T， et al. Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14; 564 (1-3) :158-66. [3]. Szabo C， et al. Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov; 55 (11) :3004-12. [4]. Clark RS， et al. Local administration of the poly (ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. J Neurotrauma. 2007 Aug; 24 (8) :1399-405 |
| Unit | Bottle |
| Specification | 200mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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怎么溶解？ 2022-07-15 17:43:40
Administrator可溶于水或者乙醇，溶解度≥1mg/mL，暂未检测饱和溶解度。如需溶解更高浓度储备液，建议超声处理。
本产品非无菌，如需无菌溶液，溶解后需过滤除菌。