Abexinostat
Cat.No:IA1710 Solarbio
CAS:783355-60-2
Molecular Formula:C21H23N3O5
Molecular Weight:397.42
Storage:Powder:2-8℃,2 years
Purity:≥98%
Appearance:Light yellow to yellow Solid
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AbexinostatCAS:783355-60-2
Molecular Formula:C21H23N3O5
Molecular Weight:397.42
Storage:Powder:2-8℃,2 years
Purity:≥98%
Appearance:Light yellow to yellow Solid
Qty:
Size:
CAS | 783355-60-2 |
Name | Abexinostat |
Molecular Formula | C21H23N3O5 |
Molecular Weight | 397.42 |
Solubility | Soluble in --- |
Purity | ≥98% |
Appearance | Light yellow to yellow Solid |
Storage | Powder:2-8℃,2 years |
EC | EINECS 811-183-9 |
MDL | MFCD10565969 |
SMILES | O=C(NCCOC1=CC=C(C=C1)C(NO)=O)C2=C(C3=CC=CC=C3O2)CN(C)C |
Target Point | HDAC |
Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
Background | Abexinostat/PCI-24781 is a novel pan-HDAC inhibitor. |
Biological Activity | Abexinostat是一种新的泛HDAC抑制剂,主要靶向HDAC1的Ki值为7 nM[1-3]。 |
Data Literature Source | [1]. Buggy JJ, et al. CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. Mol Cancer Ther, 2006, 5 (5) , 1309-1317. [2]. Adimoolam S, et al. HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination. Proc Natl Acad Sci U S A, 2007, 104 (49) , 19482-19487. [3]. Lopez G, et al. Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma. Clin Cancer Res, 2009, 15 (10) , 3472-3483. |
Unit | Bottle |
Specification | 5mg 10mg 50mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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