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Aliertib

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Cat.No：IA1740 Solarbio

CAS：1028486-01-2

Molecular Formula：C₂₇H₂₀ClFN₄O₄

Molecular Weight：518.92

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	1028486-01-2
Name	Aliertib
Molecular Formula	C₂₇H₂₀ClFN₄O₄
Molecular Weight	518.92
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 1592732-453-0
MDL	MFCD16621243
SMILES	O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O
Target Point	Aurora Kinase
Passage	Cell Cycle
Background	Aliertib/mLN 8237 is a selective Aurora A inhibitor.
Biological Activity	Alisertib 是选择性的 Aurora A 抑制剂，IC50为1.2 nM[1-4]。
IC50	Aurora A:1.2nM [1-4]
Data Literature Source	[1]. Güllü G，et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma Blood June 24，2010 vol. 115 no. 25 5202-5213 [2]. Sloane DA，et al. Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237 ACS Chem. Biol.，2010，5 (6)，pp 563-576 [3]. Manfredi MG，et al. Characterization of Alisertib (MLN8237)，an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays.Clin Cancer Res. 2011 Dec 15;17(24):7614-7624. [4]. Yayi Feng，et al. Targeting aurora a kinase (AURKA) and P21-activated kinase 1 (PAK1) in hormone receptor-positive breast cancer. College of Medicine. Drexel University. November 2016.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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