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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > BI 2536CAS：755038-02-9
Molecular Formula：C28H39N7O3
Molecular Weight：521.66
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
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| CAS | 755038-02-9 |
| Name | BI 2536 |
| Molecular Formula | C28H39N7O3 |
| Molecular Weight | 521.66 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1308068-626-2 |
| MDL | MFCD10565924 |
| SMILES | O=C1[C@H](N(C2=C(N1C)C=NC(NC3=CC=C(C(NC4CCN(C)CC4)=O)C=C3OC)=N2)C5CCCC5)CC |
| Target Point | Polo-like Kinase (PLK);BRD4;IFNβ |
| Passage | Cell Cycle;Immunology & Inflammation |
| Background | BI 2536 is a dual inhibitor of PLK1 and BRD4. BI 2536 inhibits IFNB (IFN-β, interferon β) gene transcription. |
| Biological Activity | BI 2536 is a dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively[1]. BI-2536 suppresses IFNB (encoding IFN-β) gene transcription[4]. |
| Data Literature Source | [1]. Lénárt P，et al. The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1. Curr Biol. 2007 Feb 20;17(4):304-15. [2]. Chen L，et al. BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536. ACS Med Chem Lett. 2015 May 18;6(7):764-9. [3]. Steegmaier M，et al. BI 2536，a Potent and Selective Inhibitor of Polo-like Kinase 1，Inhibits Tumor Growth In Vivo. Current Biology (2007)，17(4)，316-322. [4]. Malik N，et al. Suppression of IFN β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members. Biochem J. 2015 Jun 15;468(3):363-72. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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