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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > EverolimusCAS：159351-69-6
Molecular Formula：C53H83NO14
Molecular Weight：958.22
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 159351-69-6 |
| Name | Everolimus |
| Molecular Formula | C53H83NO14 |
| Molecular Weight | 958.22 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 621-003-9 |
| MDL | MFCD00929329 |
| SMILES | O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](OCCO)CC4)OC)C)=O)=O |
| Target Point | mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | Everolimus is a potent mTOR inhibitor. |
| Biological Activity | Everolimus (RAD001) 是有效的 mTOR 抑制剂, 它与FKBP-12结合以产生免疫抑制复合物[1-4]。 |
| IC50 | mTOR:5-6nM (IC50) [1-4] |
| Data Literature Source | [1]. O'Reilly T， et al. Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001) : Processes，Limitations， and Further Proposals. Transl Oncol. 2010 Apr; 3 (2) :65-79. [2]. Lane HA， et al. mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin Cancer Res， 2009， 15 (5) ， 1612-1622. [3]. Zhu Y， et al. Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo. Tumour Biol. 2012 Oct; 33 (5) :1349-62. [4]. Kawata T， et al. Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. Cancer Sci. 2018 Jan; 109 (1) :103-111. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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