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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > GDC-0879CAS：905281-76-7
Molecular Formula：C19H18N4O2
Molecular Weight：334.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 905281-76-7 |
| Name | GDC-0879 |
| Molecular Formula | C19H18N4O2 |
| Molecular Weight | 334.37 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O/N=C1C(C=CC(C2=CN(CCO)N=C2C3=CC=NC=C3)=C4)=C4CC/1 |
| Target Point | Raf |
| Passage | MAPK |
| Background | GDC-0879 is a potent and selective B-Raf inhibitor. |
| Biological Activity | GDC-0879 是一种有效的选择性 B-Raf 抑制剂，IC50 为 0.13 nM[1-2]。 |
| IC50 | B-Raf:0.13nM(IC50)[1-2] |
| Data Literature Source | [1]. Hansen JD，et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4692-5. [2]. Wong H，et al. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2，3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879)，a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations，phosphorylated mitogen-activated protein kinase kinase 1 inhibition，and efficacy. J Pharmacol Exp Ther. 2009 Apr;329(1):360-7. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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