Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > KU-55933

KU-55933

Manual Download

Cat.No：IK0200 Solarbio

CAS：587871-26-9

Molecular Formula：C₂₁H₁₇NO₃S₂

Molecular Weight：395.49

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to brown Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	587871-26-9
Name	KU-55933
Molecular Formula	C₂₁H₁₇NO₃S₂
Molecular Weight	395.49
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD08276985
SMILES	O=C1C=C(OC(C2=C3SC4=C(SC3=CC=C2)C=CC=C4)=C1)N5CCOCC5
Target Point	ATM/ATR
Passage	DNA Damage/DNA Repair; PI3K/Akt/mTOR
Background	KU-55933 is a potent ATM inhibitor.
Biological Activity	KU-55933 是有效的 ATM 抑制剂，IC50 和 Ki 值分别为 12.9 和 2.2 nM；对 ATM 的选择性比对 DNA-PK，PI3K/PI4K，ATR 和 mTOR 高。[1-3]
IC50	ATM:12.9nM(IC50)[1-3]
Data Literature Source	[1]. Hickson I，et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 Dec 15;64(24):9152-9 [2]. Khalil HS，et al. Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.Exp Biol Med (Maywood). 2012 Jun;237(6):622-34. Epub 2012 Jun 22. [3]. Kim YD，et al. Orphan nuclear receptor SHP negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of STAT5 transactivation.J Biol Chem. 2012 Sep 12
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.