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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > LinsitinibCAS：867160-71-2
Molecular Formula：C26H23N5O
Molecular Weight：421.49
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 867160-71-2 |
| Name | Linsitinib |
| Molecular Formula | C26H23N5O |
| Molecular Weight | 421.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1533716-785-6 |
| MDL | MFCD12912153 |
| SMILES | O[C@@]1(C)C[C@@H](C2=NC(C3=CC=C4C=CC(C5=CC=CC=C5)=NC4=C3)=C6C(N)=NC=CN62)C1 |
| Target Point | IGF-1R inhibitor;Insulin Receptor |
| Passage | Protein Tyrosine Kinase/RTK;Endocrinology & Hormones |
| Background | Losmapimod is a dual inhibitor of IGF-1 and insulin receptors. |
| Biological Activity | Losmapimod是 IGF-1 和胰岛素受体的双重抑制剂，IC50 分别为35 和 75 nM。[1-5] |
| Data Literature Source | [1]. Mulvihill MJ，et al. Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor. Future Med Chem. 2009 Sep;1(6):1153-71. [2]. McKinley ET，et al. 18FDG-PET predicts pharmacodynamic response to OSI-906，a dual IGF-1R/IR inhibitor，in preclinical mouse models of lung cancer. Clin Cancer Res. 2011 May 15;17(10):3332-40. [3]. Li W，et al. Effectiveness of inhibitor rapamycin，saracatinib，linsitinib and JNJ-38877605 against human prostate cancer cells. Int J Clin Exp Med. 2015 Apr 15;8(4):6563-7. [4]. Tajima K，et al. Metabolic recovery of lipodystrophy，liver steatosis，and pancreatic β cell proliferation after the withdrawal of OSI-906. Sci Rep. 2017 Jun 23;7(1):4119. [5]. Mayu Kyohara，et al. Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans. Endocrinology. 2017 Oct 5. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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