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Mocetinostat

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Cat.No：IM1120 Solarbio

CAS：726169-73-9

Molecular Formula：C₂₃H₂₀N₆O

Molecular Weight：396.44

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	726169-73-9
Name	Mocetinostat
Molecular Formula	C₂₃H₂₀N₆O
Molecular Weight	396.44
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00071522
SMILES	O=C(C1=CC=C(C=C1)CNC2=NC=CC(C3=CC=CN=C3)=N2)NC4=CC=CC=C4N
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	Mocetinosta is a potent HDAC (Class I/IV) inhibitor.
Biological Activity	Mocetinostat 是一种有效，同种型选择性的 HDAC (Class I/IV) 抑制剂，抑制HDAC1，HDAC2，HDAC3 和 HDAC11 的IC50分别为0.15，0.29，1.66 和 0.59 μM。 Mocetinostat对HDAC4，HDAC5，HDAC6，HDAC7或HDAC8没有抑制作用[1-2]。
IC50	HDAC1:0.15μM;HDAC2:0.29μM;HDAC11:0.59μM;HDAC3:1.66μM [1-2]
Data Literature Source	[1]. Fournel M，et al. MGCD0103，a novel isotype-selective histone deacetylase inhibitor，has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther. 2008 Apr;7(4):759-68. [2]. Cai J，et al. The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method. Biomed Res Int. 2015;2015:517295.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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