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Odanacatib

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Cat.No：IO0370 Solarbio

CAS：603139-19-1

Molecular Formula：C₂₅H₂₇F₄N₃O₃S

Molecular Weight：525.56

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to brown Solid

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Product Information

CAS	603139-19-1
Name	Odanacatib
Molecular Formula	C₂₅H₂₇F₄N₃O₃S
Molecular Weight	525.56
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 682-460-8
MDL	MFCD11042419
SMILES	N#CC1(NC([C@@H](N[C@H](C(F)(F)F)C2=CC=C(C3=CC=C(S(=O)(C)=O)C=C3)C=C2)CC(C)(F)C)=O)CC1
Target Point	Cathepsin
Passage	Metabolic Enzyme&Protease
Background	Odanacatib/MK-0822 is a potent and selective cathepsin K inhibitor.
Biological Activity	Odanacatib 是有效, 选择性的组织蛋白酶K抑制剂, IC50 分别为0.2 nM 和 1 nM[1-4]。
IC50	IC50: 0.2nM (Human Cathepsin K) ， 1nM (Rabbit Cathepsin K) [1-4]
Data Literature Source	[1]. Jacques Yves Gauthier， et al. The discovery of odanacatib (MK-0822) ， a selective inhibitor of cathepsin K. Bioorg Med Chem Lett. 2008 Feb 1; 18 (3) :923-8. [2]. Leung P， et al. The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking. Bone. 2011 Oct; 49 (4) :623-635. [3]. Ng KW. Potential role of odanacatib in the treatment of osteoporosis. Clin Interv Aging. 2012; 7:235-47. [4]. Yi C， et al. Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats. Sci Rep. 2017 Mar 17; 7:44682
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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