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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > OSU-03012CAS：742112-33-0
Molecular Formula：C26H19F3N4O
Molecular Weight：460.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 742112-33-0 |
| Name | OSU-03012 |
| Molecular Formula | C26H19F3N4O |
| Molecular Weight | 460.46 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12912272 |
| SMILES | O=C(CN)NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C4C5=CC=CC=C5C=CC4=C3)C(F)(F)F |
| Target Point | PDK-1 |
| Passage | PI3K/Akt/mTOR |
| Background | OSU-03012 is a PDK-1 inhibitor. |
| Biological Activity | OSU-03012 是一种 PDK-1 抑制剂，IC50 为 5 μM[1]。 |
| IC50 | 5μM(PDK-1)[1] |
| Data Literature Source | [1]. Zhu J，et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 Jun 15;64(12):4309-18. [2]. To K，et al. The phosphoinositide-dependent kinase-1 inhibitor 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) prevents Y-box binding protein-1 from inducing epidermal growth factor receptor. Mol Pharmacol. 2007 Sep;72(3):641-52 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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