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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Palbociclib HydrochlorideCAS：827022-32-2
Molecular Formula：C24H29N7O2·HCl
Molecular Weight：483.99
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 827022-32-2 |
| Name | Palbociclib Hydrochloride |
| Molecular Formula | C24H29N7O2·HCl |
| Molecular Weight | 483.99 |
| Solubility | Soluble in Water/DMSO ≥1mg/mL(Need ultrasonic or Water bath) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD22420809 |
| SMILES | O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.Cl |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | Palbociclib hydrochloride is a highly selective CDK4/6 inhibitor. |
| Biological Activity | Palbociclib hydrochloride是高选择性的 CDK4/6 抑制剂，IC50 分别为11 nM 和 16 nM[1-3]。 |
| IC50 | Cdk4/cyclin D3:9nM;Cdk4/cyclin D1:11nM;Cdk6/cyclin D2:16nM [1-3] |
| Data Literature Source | [1]. Fry DW，et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38. [2]. Katsumi Y，et al. Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression. Biochem Biophys Res Commun，2011，413(1)，62-68. [3]. Hsieh FS，et al. Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner. Mol Oncol. 2017 Aug;11(8):1035-1049 |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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