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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > RefametinibCAS：923032-37-5
Molecular Formula：C19H20F3IN2O5S
Molecular Weight：572.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 923032-37-5 |
| Name | Refametinib |
| Molecular Formula | C19H20F3IN2O5S |
| Molecular Weight | 572.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18633256 |
| SMILES | O=S(C1(C[C@H](O)CO)CC1)(NC(C(NC(C(F)=C2)=CC=C2I)=C3F)=C(OC)C=C3F)=O |
| Target Point | MEK |
| Passage | MAPK |
| Background | Refametinib is a potent and selective MEK1/MEK2 inhibitor |
| Biological Activity | Refametinib 是一种有效的选择性 MEK1/MEK2 抑制剂，IC50 分别为 19 nM 和 47 nM[1]。 |
| IC50 | MEK1:19nM;mEK2:47nM [1] |
| Data Literature Source | [1]. Iverson C，et al. RDEA119/BAY 869766: a potent，selective，allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009 Sep 1;69(17):6839-47 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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