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SRT1720 Hydrochloride

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Cat.No：IS1430 Solarbio

CAS：1001645-58-4

Molecular Formula：C₂₅H₂₃N₇OS·HCl

Molecular Weight：506.02

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1001645-58-4
Name	SRT1720 Hydrochloride
Molecular Formula	C₂₅H₂₃N₇OS·HCl
Molecular Weight	506.02
Solubility	Soluble in DMSO ≥10mg/mL
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18074509
SMILES	O=C(C1=NC2=CC=CC=C2N=C1)NC3=C(C=CC=C3)C4=CN5C(CN6CCNCC6)=CSC5=N4.[x HCl]
Target Point	Sirtuin
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	SRT 1720 Hydrochloride is a selective SIRT1 activator.
Biological Activity	SRT 1720 Hydrochloride 是选择性的 SIRT1 激活剂，EC1.5为 0.16 μM，对 SIRT2 和 SIRT3 的作用较弱，EC1.5 值分别为 37 μM 和 300 μM。[1-4]
Data Literature Source	[1]. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 [2]. Baur JA，et al. Are sirtuins viable targets for improving healthspan and lifespan ，Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61 [3]. Yao H，et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.，J Clin Invest. 2012 Jun 1;122(6):2032-45. [4]. Gao D，et al. Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. Hypertension. 2016 Nov;68(5):1191-1199
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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