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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AZD-5438CAS：602306-29-6
Molecular Formula：C18H21N5O2S
Molecular Weight：371.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 602306-29-6 |
| Name | AZD-5438 |
| Molecular Formula | C18H21N5O2S |
| Molecular Weight | 371.46 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11112135 |
| SMILES | O=S(C1=CC=C(NC2=NC(C3=CN=C(N3C(C)C)C)=CC=N2)C=C1)(C)=O |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | AZD-5438 is a potent CDK1/2/9 inhibitor. |
| Biological Activity | AZD-5438 是一种有效的 CDK1/2/9 抑制剂，IC50 值分别为 16 nM/6 nM/20 nM；同时抑制 GSK3β，对 CDK5/6 的作用较弱[1-2]。 |
| Data Literature Source | [1]. Byth KF，et al. AZD5438，a potent oral inhibitor of cyclin-dependent kinases 1，2，and 9，leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-66. Epub 2009 Jun 9. [2]. Raghavan P，et al. AZD5438，an Inhibitor of Cdk1，2，and 9，Enhances the Radiosensitivity of Non-Small Cell Lung Carcinoma Cells. Int J Radiat Oncol Biol Phys. 2012 Jul 12. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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