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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > ABT-751CAS：141430-65-1
Molecular Formula：C18H17N3O4S
Molecular Weight：371.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 141430-65-1 |
| Name | ABT-751 |
| Molecular Formula | C18H17N3O4S |
| Molecular Weight | 371.41 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 256-495-9 |
| MDL | MFCD00910291 |
| SMILES | COC1=CC=C(C=C1)S(=O)(NC2=C(N=CC=C2)NC3=CC=C(C=C3)O)=O |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | ABT-751/E-7010 are novel biocompatible tubulin binding agents and antimitotic sulfonamides. |
| Biological Activity | ABT-751 (Abbott Laboratories， Abbott Park， IL) is an orally bioavailable sulfonamide that binds to the colchicine binding site on β-tubulin and inhibits the polymerization of microtubules. ABT-751 had antitumor activity in a panel of 30 tumor cell lines in vitro including cell lines resistant to Vinca alkaloids and taxanes due to P-glycoprotein overexpression. ABT-751 is a novel orally available antimitotic agent that targets microtubule polymerization.[1-2] |
| Data Literature Source | [1]. Elizabeth Fox et al. A Phase I Study of ABT-751，an Orally Bioavailable Tubulin Inhibitor，Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors Clin Cancer Res February 15，2008 14; 1111 [2]. Silver M，Rusk A，Phillips B，Beck E，Jankowski M，Philibert J，Hahn K，Hershey E，McKeegan E，Bauch J，Krivoshik A，Khanna C.，Evaluation of the oral antimitotic agent (ABT-751) in dogs with lymphoma.，J Vet Intern Med. 2012 Mar-Apr;26(2):349-54. doi: 10.1 |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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