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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > AprepitantCAS：170729-80-3
Molecular Formula：C23H21F7N4O3
Molecular Weight：534.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 170729-80-3 |
| Name | Aprepitant |
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 677-636-6 |
| MDL | MFCD08277635 |
| SMILES | O=C1NC(CN2[C@H]([C@@H](O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)OCC2)C4=CC=C(F)C=C4)=NN1 |
| Target Point | Neurokinin Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | Aprepitant/MK-0869 is a selective and high affinity neurokinin 1 receptor antagonist. |
| Biological Activity | Aprepitant是选择性和高亲和力的神经激肽1受体拮抗剂，Kd 值为86 pM[1-4]。 |
| Data Literature Source | [1]. Martinez AN，et al. Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis. J Neuroinflammation. 2017 Feb 15;14(1):37. [2]. Bayati S，et al. Inhibition of tachykinin NK1 receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells. Eur J Pharmacol. 2016 Nov 15;791:274-283. [3]. Mannangatti P，et al. Differential effects of aprepitant，a clinically used neurokinin-1 receptor antagonist on the expression of conditioned psychostimulant versus opioid reward. Psychopharmacology (Berl). 2017 Feb;234(4):695-705. [4]. Barrett JS，et al. Pharmacologic rationale for the NK1R antagonist，aprepitant as adjunctive therapy in HIV. J Transl Med. 2016 May 26;14(1):148. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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