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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > BMS-387032CAS：345627-80-7
Molecular Formula：C17H24N4O2S2
Molecular Weight：380.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 345627-80-7 |
| Name | BMS-387032 |
| Molecular Formula | C17H24N4O2S2 |
| Molecular Weight | 380.53 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09833875 |
| SMILES | CC(C)(C1=CN=C(CSC2=CN=C(NC(C3CCNCC3)=O)S2)O1)C |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | SNS-032 is a selective CDK2/7/9 inhibitor. |
| Biological Activity | SNS-032 是一种选择性的 CDK2/7/9 抑制剂，IC50 值分别为 48 nM/62 nM/4 nM。[1-5] |
| IC50 | CDK9:4nM;CDK2:38nM;CDK7:62nM [1-5] |
| Data Literature Source | [1]. Chen R，et al. Mechanism of action of SNS-032，a novel cyclin-dependent kinase inhibitor，in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45. [2]. Ali MA，et al. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia. 2007 May;9(5):370-81. [3]. Conroy A，et al. SNS-032 is a potent and selective CDK 2，7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother Pharmacol. 2009 Sep;64(4):723-32. [4]. Wu Y，et al. Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.Clin Cancer Res. 2012 Apr 1;18(7):1966-78. Epub 2012 Mar 23. [5]. Walsby E，et al. The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine.Leukemia. 2011 Mar;25(3):411-9. Epub 2011 Jan 7. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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