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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > SNS-314 MesylateCAS：1146618-41-8
Molecular Formula：C18H15ClN6OS2·CH4O3S
Molecular Weight：527.04
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1146618-41-8 |
| Name | SNS-314 Mesylate |
| Molecular Formula | C18H15ClN6OS2·CH4O3S |
| Molecular Weight | 527.04 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C(NC1=CC=CC(Cl)=C1)NC2=NC=C(S2)CCNC3=C4C(C=CS4)=NC=N3.OS(C)(=O)=O |
| Target Point | Aurora Kinase |
| Passage | Cell Cycle |
| Background | SNS-314 is a potent and selective Aurora inhibitor. |
| Biological Activity | SNS-314有效，选择性的极光激酶 (aurora) 抑制剂，对极光激酶A，B，C的IC50 值分别为9，31 和6 nM。[1-2] |
| IC50 | Aurora A:9nM;Aurora B:31nM;Aurora C:6nM [1-2] |
| Data Literature Source | [1]. Oslob JD，et al. Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4. [2]. Arbitrario JP，et al. SNS-314，a pan-Aurora kinase inhibitor，shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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