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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Ubiquitin > SerdemetanCAS：881202-45-5
Molecular Formula：C21H20N4
Molecular Weight：328.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light brown to brown Solid
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| CAS | 881202-45-5 |
| Name | Serdemetan |
| Molecular Formula | C21H20N4 |
| Molecular Weight | 328.42 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light brown to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD16620518 |
| SMILES | C1(NCCC2=CNC3=C2C=CC=C3)=CC=C(C=C1)NC4=CC=NC=C4 |
| Target Point | p53 |
| Passage | Apoptosis |
| Background | Serdemetan is an HDM2 ubiquitin ligase antagonist. |
| Biological Activity | Serdemetan (JNJ-26854165)是一种HDM2泛素连接酶拮抗剂，作用于p53野生型细胞，诱导早期凋亡，在缺乏功能性p53的细胞中，抑制细胞增殖而延迟细胞凋亡。[1] |
| Data Literature Source | [1] Kojima K，et al. Mol Cancer Ther. 2010，9(9)，2545-2557. [2] Yuan Y，et al. J Hematol Oncol. 2011，4:16. [3] Chargari C，et al. Cancer Lett. 2011，312(2)，209-218. [4] Smith MA，et al. Pediatr Blood Cancer，2012，59(2)，329-332. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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