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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > SeliciclibCAS：186692-46-6
Molecular Formula：C19H26N6O
Molecular Weight：354.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 186692-46-6 |
| Name | Seliciclib |
| Molecular Formula | C19H26N6O |
| Molecular Weight | 354.45 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD02266401 |
| SMILES | OC[C@H](NC1=NC(NCC2=CC=CC=C2)=C3C(N(C=N3)C(C)C)=N1)CC |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | Roscovitine is a potent and selective inhibitor of CDKs. |
| Biological Activity | Roscovitine是有效，选择性的 CDKs 抑制剂，抑制 CDK5，CDK2 和 CDK2 的 IC50 分别为0.2 μM，0.65 μM，0.7 μM。[1-3] |
| IC50 | cdc2/cyclin B:0.65μM;cdk2/cyclin A:0.7μM;Cdk2/cyclin E2:0.7μM;CDK5/p35:0.16μM;ERK2:14μM [1-3] |
| Data Literature Source | [1]. Meijer L，et al. Biochemical and cellular effects of roscovitine，a potent and selective inhibitor of the cyclin-dependent kinases cdc2，cdk2 and cdk5. Eur J Biochem. 1997 Jan 15;243(1-2):527-36. [2]. Bai X，et al. CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via erk1/2/pparγ pathway. Oncotarget. 2016 Apr 27. [3]. Gary C，et al. Selective antitumor activity of roscovitine in head and neck cancer. Oncotarget. 2016 May 23 |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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