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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > ENMD-2076CAS：934353-76-1
Molecular Formula：C21H25N7
Molecular Weight：375.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 934353-76-1 |
| Name | ENMD-2076 |
| Molecular Formula | C21H25N7 |
| Molecular Weight | 375.47 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16619371 |
| SMILES | CC1=CC(NC2=NC(/C=C/C3=CC=CC=C3)=NC(N4CCN(CC4)C)=C2)=NN1 |
| Target Point | FLT3;Src;Aurora Kinase;RET |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK;Cell Cycle |
| Background | ENMD-2076 is a multi-targeted kinase inhibitor. |
| Biological Activity | ENMD-2076是多靶点激酶抑制剂，抑制 Aurora A，Flt3，KDR/VEGFR2，Flt4/VEGFR3，FGFR1，FGFR2，Src，PDGFRα 的IC50 值分别为1.86，14，58.2，15.9，92.7，70.8，20.2 and 56.4 nM[1-2]。 |
| Data Literature Source | [1]. Fletcher GC，et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37. [2]. Wang X，et al. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor，ENMD-2076，against multiple myeloma. Br J Haematol. 2010 Aug;150(3):313-25. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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