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Ivacaftor

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Cat.No：II0710 Solarbio

CAS：873054-44-5

Molecular Formula：C₂₄H₂₈N₂O₃

Molecular Weight：392.49

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	873054-44-5
Name	Ivacaftor
Molecular Formula	C₂₄H₂₈N₂O₃
Molecular Weight	392.49
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD17171361
SMILES	CC(C)(C1=C(C=C(C(C(C)(C)C)=C1)O)NC(C2=CNC3=C(C2=O)C=CC=C3)=O)C
Target Point	CFTR
Passage	Membrane Transporter&Ion Channel
Background	Ivacaftor is a potent CFTR synergist.
Biological Activity	Ivacaftor是一种有效的 CFTR 增效剂，靶向G551D-CFTR和F508del-CFTR的EC50分别为100 nM 和 25 nM。[1-4]
Data Literature Source	[1]. Delaunay JL，et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator，ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570 [2]. Mutyam V，et al. Therapeutic benefit observed with the CFTR potentiator，ivacaftor，in a CF patient homozygous for the W1282X CFTR nonsense mutation. J Cyst Fibros. 2017 Jan;16(1):24-29 [3]. Hadida S，et al. Discovery of N-(2，4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1，4-dihydroquinoline-3-carboxamide (VX-770，ivacaftor)，a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-9 [4]. Van Goor F，et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator，VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30.
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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