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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > OnalespibCAS：912999-49-6
Molecular Formula：C24H31N3O3
Molecular Weight：409.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 912999-49-6 |
| Name | Onalespib |
| Molecular Formula | C24H31N3O3 |
| Molecular Weight | 409.52 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00051504 |
| SMILES | OC1=CC(O)=C(C(C)C)C=C1C(N2CC(C=CC(CN3CCN(C)CC3)=C4)=C4C2)=O |
| Target Point | HSP90 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | Onalespib is a potent Hsp90 inhibitor. |
| Biological Activity | Onalespib 是一种有效的 Hsp90 抑制剂，Kd 值为 0.71 nM；对许多PPTP细胞系具有细胞毒活性[1-2]。 |
| Data Literature Source | [1]. Woodhead AJ，et al. Discovery of (2，4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1，3-dihydroisoindol-2-yl]methanone (AT13387)，a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. J Med Chem. 2010 Aug 26;53(16):5956-69. [2]. Kang MH，et al. Initial testing (Stage 1) of AT13387，an HSP90 inhibitor，by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Jul 15;59(1):185-8. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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