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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > PIK-90CAS：677338-12-4
Molecular Formula：C18H17N5O3
Molecular Weight：351.36
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 677338-12-4 |
| Name | PIK-90 |
| Molecular Formula | C18H17N5O3 |
| Molecular Weight | 351.36 |
| Solubility | Soluble in --- |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD12910483 |
| SMILES | O=C(NC1=NC2=C(C3=NCCN13)C=CC(OC)=C2OC)C4=CC=CN=C4 |
| Target Point | PI3K;DNA-PK |
| Passage | PI3K/Akt/mTOR |
| Background | PIK-90 is a PI3K and DNA-PK inhibitor. |
| Biological Activity | PIK-90 是一种 PI3K 和 DNA-PK 抑制剂，抑制 p110α, p110γ，和 DNA-PK，IC50 分别为 11, 18 和 13 nM。[1-3] |
| IC50 | p110α:11nM;PI3KC2α:47nM;DNA-PK:13nM;ATM:610nM;mTORC1:1.05μM;ATR:15μM [1-3] |
| Data Literature Source | [1]. Knight ZA，et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [2]. Niedermeier M，et al. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 2009 May 28;113(22):5549-57. [3]. Cheng CK，et al. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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