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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > VER-82576CAS：847559-80-2
Molecular Formula：C21H23Cl2N5O2S
Molecular Weight：480.41
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 847559-80-2 |
| Name | VER-82576 |
| Molecular Formula | C21H23Cl2N5O2S |
| Molecular Weight | 480.41 |
| Solubility | Soluble in --- |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| SMILES | O=C(C1=CC2=C(N=C(N=C2S1)N)C3=CC(OCCN4CCCC4)=C(C=C3Cl)Cl)NCC |
| Target Point | HSP90 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | VER-82576 is a potent and selective Hsp90 inhibitor. |
| Biological Activity | VER-82576 (NVP-BEP800) 是一种有效的选择性的 Hsp90 抑制剂，对 Hsp90β 的 IC50 值为 58 nM；对Grp94和Trap-1的选择性> 70倍，IC50为4.1±1.1和5.5±0.48μM。VER-82576 同时可较弱地抑制 Grp94 和 Trap-1 的活性，IC50 值分别为 4.1 和 5.5 μM。[1-3] |
| Data Literature Source | [1]. Massey AJ，et al. Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. Mol Cancer Ther. 2010 Apr;9(4):906-19. [2]. Niewidok N，et al. Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity. Transl Oncol. 2012 Oct;5(5):356-69. Epub 2012 Oct 1. [3]. Wu J，et al. Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70. Exp Ther Med. 2014 Sep;8(3):893-898. Epub 2014 Jun 23. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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