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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > Ralimetinib DimesylateCAS：862507-23-1
Molecular Formula：C26H37FN6O6S2
Molecular Weight：612.74
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 862507-23-1 |
| Name | Ralimetinib Dimesylate |
| Molecular Formula | C26H37FN6O6S2 |
| Molecular Weight | 612.74 |
| Solubility | Soluble in Water/DMSO ≥1mg/mL(Need ultrasonic or Water bath) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22572532 |
| SMILES | FC1=CC=C(C=C1)C2=C(NC(C(C)(C)C)=N2)C3=NC4=C(C=C3)N=C(N)N4CC(C)(C)C.OS(C)(=O)=O.OS(C)(=O)=O |
| Target Point | p38 MAPK |
| Passage | MAPK |
| Background | Ralimetinib dimesylate is a selective, ATP-competitive inhibitor of p38 MAPK α/β. |
| Biological Activity | Ralimetinib dimesylate (LY2228820) 是一种选择性，ATP竞争性的 p38 MAPK α/β 抑制剂，IC50 分别为5.3 和 3.2 nM。[1-4] |
| Data Literature Source | [1]. Mader M，et al. Imidazolyl benzimidazoles and imidazo[4，5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties. Bioorg Med Chem Lett，2008，18(1)，179-183. [2]. Ishitsuka K，et al. p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br J Haematol，2008，141(5)，598-606. [3]. Campbell RM，et al. Characterization of LY2228820 dimesylate，a potent and selective inhibitor of p38 MAPK with antitumor activity. Mol Cancer Ther. 2014 Feb;13(2):364-74. [4]. Zhang Y，et al. PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. EBioMedicine. 2015 Nov 19;2(12):1944-56. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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